Fluorescent sensing of monofunctional platinum species

• DOI: 10.1039/c4cc08077g
• Publication Date: 2015-03-11T13:00:24Z
• Authors: Clara Shen; Benjamin D. W. Ha...; Lucy J. Dawson; Kellie A. Charles; Trevor W. Hambley; Elizabeth J. New
• Keywords: Spectrometry, Fluorescence; Organoplatinum Compounds; Humans; Fluorescein; Caco-2 Cells; 01 natural sciences; Chemistry Techniques, Analytical; Fluorescent Dyes; 0104 chemical sciences

A fluorescein derivative exhibits increased fluorescence selectively in response to monofunctional platinum complexes, and can be used to study the metabolism of platinum-based chemotherapeutics.