A Nile blue based infrared fluorescent probe: imaging tumors that over-express cyclooxygenase-2

• DOI: 10.1039/c4cc08915d
• Publication Date: 2014-11-19T17:08:06Z
• Authors: Benhua Wang; Jiangli Fan; Xianwu Wang; Hao Zhu; Jingyun Wang; Huiying Mu; Xiaojun Peng
• Keywords: Penetration (warfare)

The first Golgi-localized cyclooxygenase-2 (COX-2)-specific near-infrared (NIR) fluorescent probe, Niblue-C6-IMC, able to detect cancer cells, was designed. Importantly, Niblue-C6-IMC preferentially labeled the tumors in a mouse tumor model with deep tissue penetration capacity. It may be promising molecular tool for guiding resection during surgery.