Antitumor efficacy in H22 tumor bearing mice and immunoregulatory activity on RAW 264.7 macrophages of polysaccharides from Talinum triangulare

• DOI: 10.1039/c4fo00202d
• Publication Date: 2014-06-19T15:12:51Z
• Authors: Lin Wang; Zhi-Kui Nie; Qing Zhou; Jiu-Liang Zhang; Jiao-Jiao Yin; Wei Xu; Yu Qiu; Yan-Lin Ming; Shi Liang
• Keywords: Rhamnose; Arabinose; Monosaccharide

The aim of this paper was to study the antitumor and immunoregulatory activities a polysaccharide (TTP) from Talinum triangulare. molecular weight TTP-IV 49.9 kDa. monosaccharide composition analysis revealed that it heteropolysaccharide consisting rhamnose, arabinose, mannose galactose with molar ratio 1.22 : 1.00 1.05 1.51. results in vivo showed TTP (200 mg per kg bw) significantly inhibited growth tumor by 49.07% H22-bearing Kunming mice. In vitro, primary murine macrophages promoted dose- time-dependent manner significantly. Besides, RAW 264.7 cells were activated produce NO toxicity supernatant markedly enhanced vitro. levels iNOS, TLR2, TLR4 IL-1β obviously increased TTP. Therefore, is suggested can be utilized as potent immunoenhancing material functional food.