Microfluidic cellular enrichment and separation through differences in viscoelastic deformation

• DOI: 10.1039/c4lc01150c
• Publication Date: 2014-11-11T13:06:22Z
• Authors: Gonghao Wang; Kaci Crawford; Cory Turbyfield; Wilbur Lam; Alexander Alexeev; Todd Sulchek
• Keywords: 0303 health sciences; Cell Polarity; HL-60 Cells; Cell Separation; Microfluidic Analytical Techniques; Flow Cytometry; Microscopy, Atomic Force; 03 medical and health sciences; Elastic Modulus; Leukocytes; Humans; K562 Cells; Cell Shape; Cell Size

We report a microfluidic approach to separate and enrich a mixture of two cell types based on differences in cell viscoelastic behavior during repeated compressions and relaxation events.