A lung-on-a-chip array with an integrated bio-inspired respiration mechanism

• DOI: 10.1039/c4lc01252f
• Publication Date: 2014-12-03T11:06:38Z
• Authors: Andreas O. Stucki; Janick D. Stucki; Sean R. R. Hall; Marcel Felder; Yves Mermoud; Ralph A. Schmid; Thomas Geiser; Olivier T. Guenat
• Keywords: 0301 basic medicine; Cell Survival; Interleukin-8; 610 Medicine & health; Epithelial Cells; Microfluidic Analytical Techniques; Coculture Techniques; Permeability; Pulmonary Alveoli; 03 medical and health sciences; Biomimetics; Human Umbilical Vein Endothelial Cells; Humans; Stress, Mechanical; Porosity; Cells, Cultured

The effects of respiration movements on primary lung cells from patients are investigated on an easy to handle lung-on-a-chip.