Highly enantioselective reaction of 2-oxindoles with (3-indolyl)methanols by cooperative Catalysis of a Lewis acid and organocatalyst

• DOI: 10.1039/c4ob02035a
• Publication Date: 2014-10-13T11:01:36Z
• Authors: Chuan-Li Ren; Tao Zhang; Xing-Yong Wang; Tao Wu; Jing Ma; Qing-Qing Xuan; Feng Wei; Hong-Yan Huang; Dong Wang; Li Liu
• Keywords: Indoles; Molecular Structure; Methanol; Stereoisomerism; 01 natural sciences; Catalysis; Oxindoles; 0104 chemical sciences; Alkaloids; Lewis Acids

An efficient cooperative biscinchona alkaloid and Lewis acid catalytic system was developed in the enantioselective α-alkylation of 2-oxindoles with (3-indolyl)(phenyl)methanols to provide (2-oxindole)-linker-indole derivatives in good yields (70-83%) with high enantioselectivities (81%-92%).