Highly stable triple helix formation by homopyrimidine (l)-acyclic threoninol nucleic acids with single stranded DNA and RNA

• DOI: 10.1039/c4ob02328e
• Publication Date: 2014-12-17T16:02:06Z
• Authors: Vipin Kumar; Venkitasamy Kesavan; Kurt V. Gothelf
• Keywords: Pyrimidines; Nucleic Acids; Molecular Conformation; Temperature; DNA, Single-Stranded; RNA; Butylene Glycols; Amino Alcohols; 01 natural sciences; 0104 chemical sciences; 3. Good health

Homopyrimidine acyclic (l)-threoninol nucleic acid (aTNA) was synthesized and found to form highly stable (l)-aTNA–DNA–(l)-aTNA and (l)-aTNA–RNA–(l)-aTNA triple helical structures.