Synthesis of novel dispiropyrrolothiazoles by three-component 1,3-dipolar cycloaddition and evaluation of their antimycobacterial activity

• DOI: 10.1039/c4ra11940a
• Publication Date: 2014-11-03T14:01:21Z
• Authors: Saoussen Haddad; Sarra Boudriga; François Porzio; Armand Soldera; Moheddine Askri; Dharmarajan Sriram; Perumal Yogeeswari; Michael Knorr; Yoann Rousselin; Marek M. Kubicki
• Keywords: Antimycobacterial; Component (thermodynamics)

A series of dispiropyrrolothiazoles derivatives has been synthesized screened<italic>in vitro</italic>against<italic>Mycobacterium tuberculosis</italic>H37Rv. The observed regio- and stereoselectivity the cycloaddition reaction rationalized by DFT calculations.