Encapsulation of Pt(iv) prodrugs within a Pt(ii) cage for drug delivery

• DOI: 10.1039/c4sc01892c
• Publication Date: 2014-11-24T09:30:29Z
• Authors: Yao-Rong Zheng; Kogularamanan Sun...; Timothy C. Johnstone; Stephen J. Lippard
• Keywords: Chemistry; Chemical Sciences; 540; 01 natural sciences; Biotechnology; Cancer; 0104 chemical sciences; 3. Good health

This report presents a novel strategy that facilitates delivery of multiple, specific payloads Pt(IV) prodrugs using well-defined supramolecular system. system comprises hexanuclear Pt(II) cage can host four prodrug guest molecules. Relying on host-guest interactions between adamantyl units tethered to the molecules and cage, could be encapsulated within one cage. complex, exhibiting diameter about 3 nm, has been characterized by detailed NMR spectroscopic measurements. Owing high positive charge, this nanostructure exhibits cellular uptake. Upon entering cells reacting with biological reductants such as ascorbic acid, complex releases cisplatin, which leads cell cycle arrest apoptosis. The fully assembled displays cytotoxicity comparable cisplatin against panel human cancer lines, whereas or alone exhibit lower cytotoxicity. These findings indicate potential utilising constructs for