Anti-biofouling ability and cytocompatibility of the zwitterionic brushes-modified cellulose membrane

• DOI: 10.1039/c4tb01151a
• Publication Date: 2014-08-29T15:31:03Z
• Authors: Pingsheng Liu; Qiang Chen; Li Li; Sicong Lin; Jian Shen
• Keywords: Biofouling; Protein Adsorption; Atom-transfer radical-polymerization; Surface Modification; Biocompatibility; Cationic polymerization

Blood compatibility and cytocompatibility are key requirements of blood-contacting biomaterials for biomedical applications. Here, we showed the general zwitterionic surface modification cellulose membrane (CM) substrates, via surface-initiated atom transfer radical polymerization (SI-ATRP), to enhance anti-biofouling ability without compromising substrates. Robust X-ray photoelectron spectroscopy (XPS) characterization revealed successful construction three brushes, which significantly increased hydrophilicity CM The brushes-modified substrates can reduce non-specific adsorption proteins, platelet adhesion cell attachment, indicating a generally improved ability, is comparable that benchmark anti-fouling poly(ethylene glycol) (PEG) surface. Inspired by varied in situ morphology observed on different further investigated coatings brush-modified surfaces based both 2D (cell cultured with surfaces) 3D cultures encapsulation hydrogels). This work provides promising approach enhancing blood cellulose-based materials their cytocompatibility. observation may enrich perceptions be beneficial vivo applications materials.