Evaluation of borate bioactive glass scaffolds as a controlled delivery system for copper ions in stimulating osteogenesis and angiogenesis in bone healing

• DOI: 10.1039/c4tb01355g
• Publication Date: 2014-10-30T15:01:45Z
• Authors: Hui Wang; Shichang Zhao; Jie Zhou; Youqu Shen; Wenhai Huang; Changqing Zhang; Mohamed N. Rahaman; Deping Wang
• Keywords: Bioactive Glass; Simulated body fluid

Biocompatible synthetic scaffolds with enhanced osteogenic and angiogenic capacity are of great interest for the repair large (critical size) bone defects. In this study, we investigated an approach based on controlled delivery copper (Cu) ions from borate bioactive glass stimulating angiogenesis osteogenesis in a rodent calvarial defect model. Borate (pore size = 200-400 μm) doped varying amounts Cu (0-3.0 wt% CuO) were created using polymer foam replication technique. When immersed simulated body fluid (SBF) vitro, released into medium at rate that was dependent amount simultaneously converted to hydroxyapatite (HA). At concentrations used, not cytotoxic human marrow derived stem cells (hBMSCs) cultured alkaline phosphatase activity hBMSCs increased increasing glass. implanted rat defects 8 weeks, 3 CuO showed significantly better stimulate regenerate when compared undoped scaffolds. Together, these results indicate implants is promising healing