A redox-responsive drug delivery system based on RGD containing peptide-capped mesoporous silica nanoparticles

• DOI: 10.1039/c4tb01533a
• Publication Date: 2014-10-22T11:07:38Z
• Authors: Ze-Yong Li; Jing-Jing Hu; Qi Xu; Si Chen; Hui-Zhen Jia; Yun-Xia Sun; Ren-Xi Zhuo; Xian-Zheng Zhang
• Keywords: 02 engineering and technology; 0210 nano-technology; 3. Good health

In this paper, an intracellular glutathione (GSH) responsive mesoporous silica nanoparticle (MSN-S-S-RGD) was developed as a drug nanocarrier by immobilizing the gatekeeper (RGD containing peptide) onto MSNs using disulfide bonds. The antitumor drug, DOX loaded porous structure of and DOX@MSN-S-S-RGD system has been proved to be effective nanocarrier. It determined that most could entrapped with only slight leakage. After being accumulated in tumor cells via receptor-mediated endocytosis, surface peptide layer removed trigger release kill cell due cleavage bonds GSH.