Perfluorocarbon nanodroplets stabilized by fluorinated surfactants: characterization and potentiality as theranostic agents

• DOI: 10.1039/c4tb01578a
• Publication Date: 2015-01-14T17:46:13Z
• Authors: K. Astafyeva; L. Somaglino; S. Desgranges; R. Berti; C. Patinote; D. Langevin; F. Lazeyras; R. Salomir; A. Polidori; C. Contino-Pépin; W. Urbach; N. Taulier
• Keywords: Characterization

We aim to produce emulsions that can act as contrast agents and drug carriers for cancer imaging therapy. To increase tumor detection decrease side effects, it is desirable take advantage of the enhanced permeability retention effect allows nanoparticles accumulate in tissues. do so, emulsion droplets need be small enough stable over time addition enhancing image carrying a payload. In present study, we have investigated properties potentiality theranostic perfluorocarbon stabilized by biocompatible fluorinated surfactant called FTAC. obtain better control our system, synthesis those surfactants was studied their physico-chemical were explored different configurations such micelles, droplet shell at water/air water/perfluorocarbon interfaces. The originality this work lies determination numerous characteristics including surface tension, interfacial critical micelle concentration, adiabatic compressibility, density, size distribution (aging studies), ultrasonic echogenicity. These characterization studies conducted using types FTAC several perfluorocarbons (perfluoropentane, perfluorohexane, perfluorooctyl bromide). also shown hydrophobic could encapsulated FTAC-stabilized thanks triacetin addition. Finally, detectable vitro clinical 3 T MRI scanner, equipped with double frequency 19F/1H transmit-receive coil.