PEGylated hyperbranched polyphosphoester based nanocarriers for redox-responsive delivery of doxorubicin

• DOI: 10.1039/c5bm00440c
• Publication Date: 2015-12-02T13:00:05Z
• Authors: Chao Chen; Pan Zheng; Ziyang Cao; Yinchu Ma; Jie Li; Haisheng Qian; Wei Tao; Xianzhu Yang
• Keywords: Nanocarriers

Redox-responsive polymers exhibit great potential as drug delivery systems. Herein, a redox-responsive PEGylated hyperbranched polyphosphoester (PPE) was synthesized through (A2 + B3) type polycondensation. The obtained PPE can self-assemble into nanoparticles in water. biocompatibility of the evaluated. hydrophobic chemotherapy doxorubicin (DOX) be efficiently encapsulated nanoparticles. Such DOX-loaded exhibited excellent stability due to PEGylation, and showed release behavior. In addition, flow cytometric analyses demonstrated that could internalized human breast cancer cell line MDA-MB-231, intracellular glutathione enhanced from based Therefore, such resulted inhibition tumor growth, suggesting anticancer delivery.