General CuBr2-catalyzed highly enantioselective approach for optically active allenols from terminal alkynols

• DOI: 10.1039/c5cc00697j
• Publication Date: 2015-03-06T16:03:47Z
• Authors: Xin Huang; Tao Cao; Yulin Han; Xingguo Jiang; Weilong Lin; Jiasheng Zhang; Shengming Ma
• Keywords: Bromides; Optical Phenomena; Alkynes; Stereoisomerism; Alkenes; 01 natural sciences; Catalysis; Copper; 0104 chemical sciences

A copper(ii) bromide-catalyzed highly enantioselective direct synthesis of 1,3-disubstituted allenols from commercially available aldehydes, terminal alkynols and (R)- or (S)-α,α-diphenylprolinol has been developed.