Synthesis and characterization of cell-microenvironment-sensitive leakage-free gold-shell nanoparticles with the template of interlayer-crosslinked micelles

• DOI: 10.1039/c5cc02556g
• Publication Date: 2015-05-15T09:30:38Z
• Authors: Jian Dai; Qianqian Li; Wenya Liu; Shudong Lin; Yaoyao Hao; Chao Zhang; Xintao Shuai
• Keywords: Ovarian Neoplasms; Drug Carriers; Metal Nanoparticles; Antineoplastic Agents; Hydrogen-Ion Concentration; 01 natural sciences; 0104 chemical sciences; Cross-Linking Reagents; Doxorubicin; Tumor Cells, Cultured; Tumor Microenvironment; Humans; Female; Gold; Micelles

Novel pH-GSNPs exhibit drug leakage-free behavior in a physiological environment, while achieving rapid drug release and remarkable nanogold interlayer aggregation in the intracellular microenvironment.