Direct gem-difluoromethylenation of sp3-hybridized carbon center through copper-mediated radical/radical cross-coupling for the construction of a CH2–CF2 linkage

• DOI: 10.1039/c5cc05677b
• Publication Date: 2015-08-27T10:30:40Z
• Authors: Haizhen Jiang; Minjun Xu; Wenjun Lu; Wenfeng Tian; Wen Wan; Yunrong Chen; Hongmei Deng; Shaoxiong Wu; Jian Hao
• Keywords: Bromides; Benzoxazoles; Alkylation; Free Radicals; Hydrocarbons, Fluorinated; 01 natural sciences; Catalysis; 3. Good health; 0104 chemical sciences; Cyclic N-Oxides; Benzyl Compounds; Benzimidazoles; Benzothiazoles; Oxidation-Reduction; Copper

An efficient gem-difluoromethylenation of benzyl bromides through copper-mediated direct radical/radical C–C cross-coupling has been developed for the construction of CH2–CF2 linkage.