Direct gem-difluoromethylenation of sp3-hybridized carbon center through copper-mediated radical/radical cross-coupling for the construction of a CH2–CF2 linkage

• DOI: 10.1039/c5cc05677b
• Publication Date: 2015-08-27T10:30:40Z
• Authors: Haizhen Jiang; Minjun Xu; Wenjun Lu; Wenfeng Tian; Wen Wan; Yunrong Chen; Hongmei Deng; Shaoxiong Wu; Jian Hao
• Keywords: Carbon fibers; Center (category theory); Linkage (software)

An efficient <italic>gem</italic>-difluoromethylenation of benzyl bromides through copper-mediated direct radical/radical C–C cross-coupling has been developed for the construction CH₂–CF₂ linkage.