Direct gem-difluoromethylenation of sp3-hybridized carbon center through copper-mediated radical/radical cross-coupling for the construction of a CH2–CF2 linkage

Bromides Benzoxazoles Alkylation Free Radicals Hydrocarbons, Fluorinated 01 natural sciences Catalysis 3. Good health 0104 chemical sciences Cyclic N-Oxides Benzyl Compounds Benzimidazoles Benzothiazoles Oxidation-Reduction Copper
DOI: 10.1039/c5cc05677b Publication Date: 2015-08-27T10:30:40Z
ABSTRACT
An efficient gem-difluoromethylenation of benzyl bromides through copper-mediated direct radical/radical C–C cross-coupling has been developed for the construction of CH2–CF2 linkage.
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