Differential behaviour of cationic triphenylamine derivatives in fixed and living cells: triggering and imaging cell death

• DOI: 10.1039/c5cc05970d
• Publication Date: 2015-08-17T10:01:00Z
• Authors: R. Chennoufi; H. Bougherara; N. Gagey-Eilstein; B. Dumat; E. Henry; F. Subra; F. Mahuteau-Betzer; P. Tauc; M.-P. Teulade-Fichou; E. Deprez
• Keywords: [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics; Aniline Compounds; Cell Death; Cations; Cell Line, Tumor; Humans; 01 natural sciences; 0104 chemical sciences

Nuclear staining by cationic triphenylamines is spontaneous in fixed cells while a cytoplasm–nucleus translocation is strictly dependent on light illumination in living cells and concomitant to a fast cell death process.