Isonitrile alkylations: a rapid route to imidazo[1,5-a]pyridines

• DOI: 10.1039/c5cc08724d
• Publication Date: 2015-12-22T13:04:08Z
• Authors: Yajun Li; Allen Chao; Fraser F. Fleming
• Keywords: Alkylation; Molecular Structure; Pyridines; Nitriles; Imidazoles; 16. Peace & justice; 01 natural sciences; 0104 chemical sciences; 3. Good health

Metalated arylmethylisonitriles readily add to 2-chloropyridines afford imidazo[1,5-a]pyridines. Analogous additions imidoyl chlorides and a chloroquinoline provide imidazoles an imidazo[1,5-a]quinolone which, like imidazo[1,5-a]pyridines, are valuable heterocycles for pharmaceutical synthesis.