A phosphinate-based near-infrared fluorescence probe for imaging the superoxide radical anion in vitro and in vivo

• DOI: 10.1039/c5cc09976e
• Publication Date: 2016-01-05T10:37:37Z
• Authors: Jianjian Zhang; Chuwen Li; Rui Zhang; Fengyuan Zhang; Wei Liu; Xiaoyan Liu; Simon Ming-Yuen Lee; Haixia Zhang
• Keywords: Infrared Rays; Hep G2 Cells; In Vitro Techniques; Phosphinic Acids; 01 natural sciences; 0104 chemical sciences; Mice; Limit of Detection; Superoxides; Animals; Humans; Zebrafish; Fluorescent Dyes

A novel near-infrared (NIR), turn-on fluorescence probeCyRcontaining a phosphinate group as a recognizing moiety for the selective detection of O2˙−with a low limit of detection (LOD, 9.9 nM) was developed.