Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells

• DOI: 10.1039/c5ib00032g
• Publication Date: 2015-07-03T11:01:14Z
• Authors: Erdem Tabdanov; Sasha Gondarenko; Sudha Kumari; Anastasia Liapis; Michael L. Dustin; Michael P. Sheetz; Lance C. Kam; Thomas Iskratsch
• Keywords: CD4-Positive T-Lymphocytes; 0301 basic medicine; Immunological Synapses; ligand; Ligands; Lymphocyte Activation; immunology; myosin adenosine triphosphatase; Models; T lymphocyte; Cells, Cultured; Cytoskeleton; Antigen Presentation; Cultured; immunological synapse; cytoskeleton; Lymphocyte Function-Associated Antigen-1; Biomechanical Phenomena; Immunological; priority journal; actin; lymphocyte antigen receptor; force; signal transduction; Signal Transduction; 570; Cells; Receptors, Antigen, T-Cell; protein assembly; 610; Antigen-Presenting Cells; lymphocyte function associated antigen 1; Article; T lymphocyte activation; biomechanics; 03 medical and health sciences; Cell Adhesion; Humans; controlled study; leukocyte adherence; human; lymphocyte activation; CD4+ T lymphocyte; cell culture; human cell; Models, Immunological; 500; cell adhesion; biological model; actin related protein 2-3 complex; Actins; antigen presentation; downstream processing; antigen presenting cell; physiology; T lymphocyte receptor; metabolism

Micropatterning of T cell ligands reveals their specific contributions to actin assembly and the generation of cytoskeletal forces in immunesynapse formation.