Integrative bioinformatics and proteomics-based discovery of an eEF2K inhibitor (cefatrizine) with ER stress modulation in breast cancer cells

• DOI: 10.1039/c5mb00848d
• Publication Date: 2016-01-11T11:36:17Z
• Authors: Zhiqiang Yao; Juntang Li; Zhongyu Liu; Lu Zheng; Naijun Fan; Ying Zhang; Nan Jia; Jingjing Lv; Ningning Liu; Xiaoshan Zhu; Jiangbo Du; Ci Lv; Feng Xie; Yigang Liu; Xingke Wang; Zhou Fei; Chunfang Gao
• Keywords: Elongation Factor 2 Kinase; Proteomics; 0301 basic medicine; 0303 health sciences; Computational Biology; Breast Neoplasms; Endoplasmic Reticulum Stress; 3. Good health; 03 medical and health sciences; Cell Line, Tumor; Cefatrizine; Humans; Female; Protein Kinase Inhibitors; Cell Proliferation

eEF2K, a unique calcium/calmodulin-dependent protein kinase, may regulate ER stress in cancer.