Substituted 4-hydroxy-1,2,3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches

• DOI: 10.1039/c5md00182j
• Publication Date: 2015-05-28T10:30:28Z
• Authors: Agnese C. Pippione; Franco Dosio; Alex Ducime; Antonella Federico; Katia Martina; Stefano Sainas; Bente Frølund; Major Gooyit; Kim D. Janda; Donatella Boschi; Marco L. Lolli
• Keywords: 0301 basic medicine; 03 medical and health sciences; Biochemistry, 1,2,3 triazole derivative, 4 hydroxy 1,2,3 triazole derivative, chitinase, enzyme inhibitor

The hydroxytriazole system is here analysed and used to modulate acidic moieties present in lead compounds.