Speciation of metal-based nanomaterials in human serum characterized by capillary electrophoresis coupled to ICP-MS: a case study of gold nanoparticles

• DOI: 10.1039/c5mt00109a
• Publication Date: 2015-06-12T11:00:45Z
• Authors: Magdalena Matczuk; Karolina Anecka; Federica Scaletti; Luigi Messori; Bernhard K. Keppler; Andrei R. Timerbaev; Maciej Jarosz
• Keywords: Male; 104002 Analytische Chemie; Metal Nanoparticles; ALBUMIN; PLASMA-MASS SPECTROMETRY; TRANSFERRIN; THERAPY; 01 natural sciences; Mass Spectrometry; 106023 Molekularbiologie; 104002 Analytical chemistry; Limit of Detection; Humans; 210004 Nanomaterials; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; Particle Size; 104003 Inorganic chemistry; ENGINEERED NANOPARTICLES; Electrophoresis, Capillary; Reproducibility of Results; Blood Proteins; 106023 Molecular biology; 0104 chemical sciences; SIZE; SEPARATION; Gold; PARTICLE; 104003 Anorganische Chemie; 210004 Nanomaterialien

A high-resolution CE-ICP-MS method is presented for monitoring and comprehensive understanding of the protein-mediated transformations of gold nanoparticles in human serum.