Development of an efficient route toward meiogynin A-inspired dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins

• DOI: 10.1039/c5ob00354g
• Publication Date: 2015-04-07T10:43:25Z
• Authors: Sandy Desrat; Camille Remeur; Fanny Roussi
• Keywords: Aldehydes; Cyclohexanones; bcl-X Protein; Naphthalenes; Ligands; 01 natural sciences; 0104 chemical sciences; 3. Good health; bcl-2 Homologous Antagonist-Killer Protein; [CHIM]Chemical Sciences; Myeloid Cell Leukemia Sequence 1 Protein; Sesquiterpenes; Chromatography, High Pressure Liquid; BH3 Interacting Domain Death Agonist Protein

The synthesis, on a large scale, with very good yield and er via an efficient strategy, of a chiral 4-substituted 2-cyclohexenone intermediate, was a milestone in the synthesis of seven analogues of meiogynin A, a natural sesquiterpenoid dimer.