Probing heterobivalent binding to the endocytic AP-2 adaptor complex by DNA-based spatial screening

• DOI: 10.1039/c5ob00943j
• Publication Date: 2015-06-18T15:03:30Z
• Authors: F. Diezmann; L. von Kleist; V. Haucke; O. Seitz
• Keywords: 0301 basic medicine; Base Sequence; Molecular Sequence Data; Adaptor Protein Complex 2; Brain; DNA; Endocytosis; Recombinant Proteins; Protein Structure, Tertiary; Rats; 03 medical and health sciences; Animals; Amino Acid Sequence; Protein Multimerization; Peptides; Protein Binding

The DNA-programmed peptide display in brain extract revealed a co-operation between the binding sites on the AP-2 alpha-appendage domain.