An economical synthesis of substituted quinoline-2-carboxylates through the potassium persulfate-mediated cross-dehydrogenative coupling of N-aryl glycine derivatives with olefins

• DOI: 10.1039/c5ob02216a
• Publication Date: 2015-12-01T11:07:29Z
• Authors: Guoliang Liu; Jiarui Qian; Jing Hua; Feng Cai; Xia Li; Lei Liu
• Keywords: Potassium persulfate; Quinoline; Persulfate

A practical and economical K2S2O8-mediated oxidative cross-dehydrogenative coupling of N-aryl glycine derivatives with olefins has been established, affording structurally diverse quinoline-2-carboxylates in good to high efficiency. The low cost, negligible toxicity, ease handling K2S2O8 combined the absence hazardous byproducts easy workup consisting simple filtration are attractive based on economic environmental factors.