A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters

• DOI: 10.1039/c5ob02630j
• Publication Date: 2016-01-18T16:32:26Z
• Authors: Petar O. Nikiforov; Sachin Surade; Michal Blaszczyk; Vincent Delorme; Priscille Brodin; Alain R. Baulard; Tom L. Blundell; Chris Abell
• Keywords: Ethionamide; Fragment (logic)

With the ever-increasing instances of resistance to frontline TB drugs there is need develop novel strategies fight worldwide epidemic.