Metal free direct formation of various substituted pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5-amines and their further functionalization

• DOI: 10.1039/c5ra03703d
• Publication Date: 2015-04-16T08:31:06Z
• Authors: Z. Tber; M.-A. Hiebel; H. Allouchi; A. El Hakmaoui; M. Akssira; G. Guillaumet; S. Berteina-Raboin
• Keywords: Surface Modification

Original substituted pyrido[2′,1′:2,3]imidazo[4,5-<italic>c</italic>]isoquinolin-5-amines have been easily prepared <italic>via</italic> an Groebke–Blackburn–Bienaymé MCR, then N-deprotection followed by a spontaneous final cyclization step.