Aptamer–conjugated graphene oxide–gold nanocomposites for targeted chemo-photothermal therapy of cancer cells

• DOI: 10.1039/c5tb00134j
• Publication Date: 2015-04-10T23:22:15Z
• Authors: Xinhuan Wang; Qiusen Han; Ning Yu; Jingying Li; Lin Yang; Rong Yang; Chen Wang
• Keywords: Aptamer; Photothermal effect; Cancer Therapy; Targeted Therapy

The current cancer therapies in clinical practice demonstrate the need for improvements such as improving efficiency and reducing severe side effects. Herein, we integrated targeted chemotherapy photothermal therapy a multifunctional drug-delivery platform. targeting DNA aptamer (Apt)-modified graphene oxide-gold nanoparticle (GO-AuNP) composites were successfully synthesized. doxorubicin (DOX)-loaded GO-AuNP-Apt system showed heat-stimulative sustained release characteristics. In vitro cell cytotoxicity experiments that combined had highest rate of death tumor cells compared to single or chemotherapy. Furthermore, aptamer-modification could significantly enhance accumulation nanocomposites within cells. Our study demonstrates aptamer-modified GO-Au may have potential development against