Fast solid-phase extraction of N-linked glycopeptides by amine-functionalized mesoporous silica nanoparticles

• DOI: 10.1039/c6an00285d
• Publication Date: 2016-03-11T11:46:20Z
• Authors: Weili Miao; Cheng Zhang; Yan Cai; Ying Zhang; Haojie Lu
• Keywords: Time Factors; Nitrogen; Solid Phase Extraction; Glycopeptides; Humans; 02 engineering and technology; Amines; Silicon Dioxide; 0210 nano-technology

For the first time, mesoporous material has been introduced into N-glycoproteome extraction based on a reductive amination reaction, which greatly enhanced the enrichment efficiency and deglycosylation efficiency.