Local delivery of doxorubicin through supramolecular peptide amphiphile nanofiber gels

• DOI: 10.1039/c6bm00656f
• Publication Date: 2016-11-07T09:55:45Z
• Authors: Goksu Cinar; Ayse Ozdemir; Seren Hamsici; Gokhan Gunay; Aykutlu Dana; Ayse B. Tekinay; Mustafa O. Guler
• Keywords: Cell viability; Mouse; Cytotoxicity; Nanofibers; Controlled delivery; amphophile; 01 natural sciences; Animal tissue; Chemical phenomena; Surfactant; drug delivery system; breast carcinoma; Peptide amphiphiles; drug release; Priority journal; Photobleaching; breast tumor; Breast cancer cell line; Drug release; Nanoencapsulation; peptide; 3. Good health; Biodegradability; female; priority journal; Physical chemistry; Peptide; cytotoxicity; Chemotherapeutic drugs; Bleaching; Biocompatibility; Female; Fluorescence recovery; Amphophile; Hydrophobic and Hydrophilic Interactions; gel; surfactant; animal experiment; Breast carcinoma; Drug delivery system; Breast tumor; Breast Neoplasms; chemistry; doxorubicin; Article; animal tissue; nanoencapsulation; Surface-Active Agents; breast cancer cell line; physical chemistry; Humans; controlled study; Animal model; Animal experiment; nanofiber; Hydrophobic and hydrophilic; cell viability; mouse; Tumors; nonhuman; Breast cancer treatment; concentration (parameters); animal model; Polypeptides; bleaching; Amphiphiles; Drug delivery applications; Nanofiber; Molecules; 540; Nonhuman; 0104 chemical sciences; Doxorubicin; chemical phenomena; Concentration (parameters); Physical and chemical properties; Supramolecular chemistry; Peptides; Controlled study; Gels

Peptide amphiphiles (PAs) self-assemble into supramolecular nanofiber gels that provide a suitable environment for encapsulation of both hydrophobic and hydrophilic molecules. The PA have significant advantages controlled delivery applications due to their high capacity retain water, biocompatibility, biodegradability. In this study, we demonstrate injectable drug applications. Doxorubicin (Dox), as widely used chemotherapeutic breast cancer treatment, was encapsulated within the prepared at different concentrations. Physical chemical properties were characterized, slow release Dox molecules through studied. addition, diffusion constants estimated using fluorescence recovery after photobleaching (FRAP) method. did not show any cytotoxicity strategy enhanced activity on cellular viability prolonged compared direct administration under in vitro conditions. Moreover, local vivo injection (Dox/PA) tumor site demonstrated lowest growth rate increased apoptotic cells tissue