Thioether bond formation by SPASM domain radical SAM enzymes: Cα H-atom abstraction in subtilosin A biosynthesis

• DOI: 10.1039/c6cc01317a
• Publication Date: 2016-04-04T14:31:31Z
• Authors: Alhosna Benjdia; Alain Guillot; Benjamin Lefranc; Hubert Vaudry; Jérôme Leprince; Olivier Berteau
• Keywords: Thioether

The radical SAM enzyme AlbA has been reported to catalyze the formation of a thioether bond in antibiotic subtilosin A. By modeling, biochemical and synthetic approaches, we propose novel mechanistic perspectives on this emerging group enzymes.