Phosphate bioisostere containing amphiphiles: a novel class of squaramide-based lipids

• DOI: 10.1039/c6cc04089f
• Publication Date: 2016-06-27T16:35:38Z
• Authors: Abhishek Saha; Subhankar Panda; Saurav Paul; Debasis Manna
• Keywords: Squaramide; Bioisostere

We describe a novel class of amphiphiles with squaramide moiety as phosphate bioisostere. Most synthesized squaramide-based have the favorable physicochemical properties lipids, such as: formation stable liposomes or giant unilamellar vesicles in aqueous solution, high phase-transition temperature, low vesicle leakage and phospholipase resistance properties.