C8–H bond activation vs. C2–H bond activation: from naphthyl amines to lactams

• DOI: 10.1039/c6cc06358f
• Publication Date: 2016-10-17T07:54:35Z
• Authors: Renyi Shi; Lijun Lu; Hangyu Xie; Jingwen Yan; Ting Xu; Hua Zhang; Xiaotian Qi; Yu Lan; Aiwen Lei
• Keywords: Carbonylation; Surface Modification; Cyclic amines

Pd-catalyzed selective amine-oriented C8-H bond functionalization/N-dealkylative carbonylation of naphthyl amines has been achieved. The amine group from dealkylation is proposed to be the directing for promoting this process. It represents a straightforward and easy method access various biologically important benzo[cd]indol-2(1H)-one derivatives.