Structural characterization, molecular modification and hepatoprotective effect of melanin from Lachnum YM226 on acute alcohol-induced liver injury in mice

• DOI: 10.1039/c6fo00333h
• Publication Date: 2016-08-03T10:30:32Z
• Authors: Sheng Song; Shenglan Li; Nana Su; Jinglei Li; Fang Shi; Ming Ye
• Keywords: Male; Melanins; 0301 basic medicine; Glucosamine; Glutathione Peroxidase; 0303 health sciences; Cell Survival; Alanine Transaminase; Hep G2 Cells; Glutathione; Antioxidants; 3. Good health; Disease Models, Animal; Mice; 03 medical and health sciences; Ascomycota; Liver; Cyclooxygenase 2; Alcohols; Animals; Cytokines; Humans; Aspartate Aminotransferases; Liver Diseases, Alcoholic

In this paper, we obtained the possible structural formula of the intracellular melanin of Lachnum YM226 and evaluated the protective effect of this melanin and itsd-glucosamine-modified product on acute alcohol-induced liver injury in mice.