Discovering potential cancer driver genes by an integrated network-based approach

• DOI: 10.1039/c6mb00274a
• Publication Date: 2016-07-05T09:03:56Z
• Authors: Kai Shi; Lin Gao; Bingbo Wang
• Keywords: 0301 basic medicine; Computational Biology; Reproducibility of Results; Genomics; Oncogenes; 3. Good health; Gene Expression Regulation, Neoplastic; 03 medical and health sciences; Cell Transformation, Neoplastic; Gene Frequency; Neoplasms; Mutation; Humans; Gene Regulatory Networks; Algorithms

An integrated network-based approach is proposed to nominate driver genes. It composed of two steps including a network diffusion step and an aggregated ranking step, which fuses the correlation between gene mutations expression, relationship mutated genes heterogeneous characteristic patient mutation.