The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase

• DOI: 10.1039/c6md00636a
• Publication Date: 2017-02-08T13:53:38Z
• Authors: Kyle J. Eastman; Kyle Parcella; Kap-Sun Yeung; Katharine A. Gran...; Juliang Zhu; Tao Wang; Zhongxing Zhang; Zhiwei Yin; Brett R. Beno; Steven Sheriff; Kevin Kish; Jeffrey Tredup; Adam G. Jardel; Vivek Halan; Kaushik Ghosh; Dawn Parker; Kathy Mosure; Hua Fang; Ying-Kai Wang; Julie Lemm; Xiaoliang Zhuo; Umesh Hanumegowda; Karen Rigat; Maria Donoso; Maria Tuttle; Tatyana Zvyaga; Zuzana Haarhoff; Nicholas A. Meanwell; Matthew G. Soars; Susan B. Roberts; John F. Kadow
• Keywords: 0301 basic medicine; 0303 health sciences; 03 medical and health sciences; 8. Economic growth; 3. Good health

A series of novel 7-azabenzofurans exhibiting pan-genotype inhibition of HCV NS5B polymerase via binding to the primer grip site is presented.