Injectable silver nanosensors: in vivo dosimetry for external beam radiotherapy using positron emission tomography

• DOI: 10.1039/c6nr00201c
• Publication Date: 2016-04-27T09:31:56Z
• Authors: A. N. Christensen; J. S. Rydhög; R. V. Søndergaard; T. L. Andresen; S. Holm; P. Munck af Rosen...; K. Conradsen; R. I. Jølck
• Keywords: Nanosensor; External beam radiotherapy

Development of safe and efficient radiotherapy routines requires quantification the delivered absorbed dose to cancer tissue in individual patients. In vivo dosimetry can provide accurate information about during treatment. current study, a novel silver-nanosensor formulation based on poly(vinylpyrrolidinone)-coated silver nanoparticles formulated gelation matrix composed sucrose acetate isobutyrate has been developed for use as an dosimeter external beam radiotherapy. situ photonuclear reactions trigger formation radioactive 106Ag, which enables post treatment verification using positron emission tomography imaging. The was investigated equivalent thorax phantom clinical settings workflow both standard fractionated (2 Gy) stereotactic (10- 22 high-energy setting (18 MV). provided high radiopacity planning CT-scans sufficient patient positioning image-guided dosimetric with 10% 8% deviation regimens, 10 Gy, respectively.