Efficient synthesis of pyrrolo[1,2-a]quinoxalines catalyzed by a Brønsted acid through cleavage of C–C bonds

• DOI: 10.1039/c6ob01401a
• Publication Date: 2016-08-10T09:03:05Z
• Authors: Caixia Xie; Lei Feng; Wanli Li; Xiaojun Ma; Xinkun Ma; Yihan Liu; Chen Ma
• Keywords: Brønsted–Lowry acid–base theory; Domino; Imine; Cleavage (geology); Bond cleavage; Cascade reaction; Reaction conditions

An efficient and convenient one-pot domino reaction for the direct synthesis of pyrrolo[1,2-a]quinoxalines has been developed. This approach utilizes an imine formation reaction, SEAr cleavage C-C bonds catalyzed by a Brønsted acid. β-Diketones β-keto esters are both well tolerated to give corresponding products in moderate excellent yields.