Modular access to vicinally functionalized allylic (thio)morpholinonates and piperidinonates by substrate-controlled annulation of 1,3-azadienes with hexacyclic anhydrides

• DOI: 10.1039/c6ob01526c
• Publication Date: 2016-09-05T09:00:40Z
• Authors: Hannah Braunstein; Spencer Langevin; Monique Khim; Jonathan Adamson; Katie Hovenkotter; Lindsey Kotlarz; Brandon Mansker; Timothy K. Beng
• Keywords: Annulation; Thio-

A modular substrate-controlled hexannulation of inherently promiscuous 1,3-azadienes with hexacyclic anhydrides, which affords versatile vicinally functionalized allylic lactams, in high yields, regio- and stereoselectivities is described.