I2-TBHP-catalyzed one-pot highly efficient synthesis of 4,3-fused 1,2,4-triazoles from N-tosylhydrazones and aromatic N-heterocycles via intermolecular formal 1,3-dipolar cycloaddition

• DOI: 10.1039/c6ob01926a
• Publication Date: 2016-10-20T10:54:33Z
• Authors: Surendra Babu Inturi; Biswajit Kalita; A. Jafar Ahamed
• Keywords: Formal synthesis

I2-TBHP-catalyzed azomethine imine generation and subsequent regioselective 1,3-dipolar cycloaddition (DC) with aromatic N-heterocycles was developed to afford various 4,3-fused 1,2,4-triazoles in excellent yields. The method is operationally simple highly efficient broad functional group tolerance.