C–H functionalization of amines with aryl halides by nickel-photoredox catalysis

• DOI: 10.1039/c6sc02815b
• Publication Date: 2016-07-28T18:00:15Z
• Authors: Derek T. Ahneman; Abigail G. Doyle
• Keywords: Photoredox catalysis; Surface Modification; Aryl radical; Reactivity; Aryl halide

We describe the functionalization of α-amino C-H bonds with aryl halides using a combination nickel and photoredox catalysis. This direct C-H, C-X coupling uses inexpensive readily available starting materials to generate benzylic amines, an important class bioactive molecules. Mechanistically, this method features arylation radicals mediated by catalyst. reactivity is demonstrated for range N-aryl orthogonal scope existing activation methodologies. also report reactions several complex halides, demonstrating potential utility approach in late-stage functionalization.