Neodymium-doped NaHoF4 nanoparticles as near-infrared luminescent/T2-weighted MR dual-modal imaging agents in vivo

• DOI: 10.1039/c6tb01961g
• Publication Date: 2016-12-05T09:54:45Z
• Authors: Yamin Feng; Qingbo Xiao; Yanhui Zhang; Fujin Li; Yanfang Li; Chunyan Li; Qiangbin Wang; Liyi Shi; Hongzhen Lin
• Keywords: Coprecipitation

The achievement of efficient near-infrared (NIR) luminescence lanthanide ions in a paramagnetic nanoparticle (NP) host is highly desirable to optimize the performance multimodal bioprobes. Herein, we present facile coprecipitation method prepare uniform NaHoF4:Nd3+ nanoplates. Upon NIR excitation at 785 nm, Nd3+ can be obtained from NaHoF4 hosts. More interestingly, due energy transfer excited state adjacent Ho3+, emission around 1200 nm Ho3+ also observed. r2 value NPs reaches 143.7 s-1 mM-1 high magnetic field 11.7 T. By modifying with hydrophilic alpha-cyclodextrin, were further successfully applied for luminescent/T2-weighted MR dual-modal vivo imaging nude mice, contrast liver and T2-weighted stem cells mouse brain using as