Protease-sensitive atelocollagen hydrogels promote healing in a diabetic wound model

• DOI: 10.1039/c6tb02268e
• Publication Date: 2016-10-18T16:53:36Z
• Authors: Giuseppe Tronci; Jie Yin; Roisin A. Holmes; He Liang; Stephen J. Russell; David J. Wood
• Keywords: Type I collagen; Gelatin

The design of exudate-managing wound dressings is an established route to accelerated healing, although such remains a challenge from material and manufacturing standpoints. Aiming towards the clinical translation knowledge gained in vitro with highly-swollen rat tail collagen hydrogels, this study investigated healing capability diabetic mouse model telopeptide-free, protease-inhibiting networks. 4-Vinylbenzylation UV irradiation type I atelocollagen (AC) led hydrogel networks chemical macroscopic properties comparable previous analogues, attributable similar lysine content dichroic properties. After 4 days vitro, hydrogels induced nearly 50 RFU% reduction matrix metalloproteinase (MMP)-9 activity, whilst showing less than 20 wt% mass loss. vivo, dry promoted 99% closure 10 × mm full thickness wounds neo-dermal tissue formation compared Mepilex®. This system can be equipped multiple, customisable functions key personalised chronic care.