Codelivery of sorafenib and GPC3 siRNA with PEI-modified liposomes for hepatoma therapy

• DOI: 10.1039/c7bm00866j
• Publication Date: 2017-10-23T17:10:06Z
• Authors: Weitong Sun; Yong Wang; Mingyue Cai; Liteng Lin; Xiaoyan Chen; Zhong Cao; Kangshun Zhu; Xintao Shuai
• Keywords: Niacinamide; 0303 health sciences; Carcinoma, Hepatocellular; Phenylurea Compounds; Liver Neoplasms; Gene Transfer Techniques; Apoptosis; Hep G2 Cells; Sorafenib; Combined Modality Therapy; 3. Good health; Mice; 03 medical and health sciences; Drug Delivery Systems; Glypicans; Drug Resistance, Neoplasm; Liposomes; Animals; Humans; RNA, Small Interfering; Cell Proliferation

A novel liposomal system incorporating branched PEI was prepared to efficiently codeliver sorafenib and GPC3 siRNA for hepatocellular carcinoma therapy.