Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies

• DOI: 10.1039/c7cc02059g
• Publication Date: 2017-04-25T14:19:54Z
• Authors: Hui Cai; Jared Orwenyo; Javier Guenaga; John Giddens; Christian Toonstra; Richard T. Wyatt; Lai-Xi Wang
• Keywords: 0301 basic medicine; 0303 health sciences; 03 medical and health sciences; Antibody Specificity; Polysaccharides; 13. Climate action; Glycopeptides; HIV-1; HIV Antibodies; HIV Envelope Protein gp120; Peptide Fragments; Protein Binding; 3. Good health

Synthetic bi- and trivalent HIV V3 glycopeptides show a significantly enhanced affinity for HIV-neutralizing antibody 10-1074.