Highly efficient complexation of sanguinarine alkaloid by carboxylatopillar[6]arene: pKashift, increased solubility and enhanced antibacterial activity

• DOI: 10.1039/c7cc02799k
• Publication Date: 2017-05-30T10:38:25Z
• Authors: Guchuan Ping; Yiliang Wang; Lingyun Shen; Yuting Wang; Xiaoshi Hu; Junyi Chen; Bingwen Hu; Lei Cui; Qingbin Meng; Chunju Li
• Keywords: Benzophenanthridines; Staphylococcus aureus; Macrocyclic Compounds; Dose-Response Relationship, Drug; Molecular Structure; Microbial Sensitivity Tests; Hydrogen-Ion Concentration; Isoquinolines; 01 natural sciences; Anti-Bacterial Agents; 0104 chemical sciences; Structure-Activity Relationship; Alkaloids; Solubility

Efficient complexation of sanguinarine by carboxylatopillar[6]arene. The pKashift, increased solubility, and enhanced antibacterial activity are described.