Transition-metal-free synthesis of β-trifluoromethylated enamines with trifluoromethanesulfinate

• DOI: 10.1039/c7cc03125d
• Publication Date: 2017-06-12T14:54:32Z
• Authors: Huanfeng Jiang; Wei Huang; Yue Yu; Songjian Yi; Jiawei Li; Wanqing Wu
• Keywords: 01 natural sciences; 0104 chemical sciences

We have developed a transition-metal free trifluoromethylation protocol between enamines and CF3SO2Na. A wide range of β-trifluoromethyl substituted were delivered in moderate to high yields with only E-configurations.