Enhanced cancer therapy by the marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(iii) complexes

• DOI: 10.1039/c7cc05518h
• Publication Date: 2017-08-14T13:34:05Z
• Authors: Jiangping Liu; Chengzhi Jin; Bo Yuan; Yu Chen; Xingguo Liu; Liangnian Ji; Hui Chao
• Keywords: 01 natural sciences; 3. Good health; 0104 chemical sciences

A series of DCA-Ir(iii) co-drug complexes were demonstrated to act in synergy by sensitizing cancer cell for PDT to achieve cancer-specifically enhanced two-photon PDT in the hypoxic muticellular tumor spheroids.